Multiple system atrophy (MSA) is a disorder of the nervous system.
MSA is sometimes called a Parkinson’s plus syndrome because many of the symptoms are similar. There are different types MSA based on symptoms. Once symptoms develop, the average life expectancy is 10 years or less.
The cause of MSA is unknown. Genetic factors may play a role in some families.
The symptoms are caused by degeneration of nerves throughout the brain and spinal cord. These nerves control automatic functions like balance and muscle coordination. The damage to the nerve may be caused by a buildup of a specific protein but this is not a confirmed cause.
Symptoms of MSA can vary greatly. Initial symptoms are similar to those of Parkinson disease. These initial symptoms may also be determined by the type of MSA:
- Type MSA-A is associated with orthostatic hypotension. This is a problem managing blood pressure when moving from sitting to standing. It can lead to lightheadedness or fainting.
Type MSA-P is associated with symptoms similar to initial Parkinson symptoms such as:
- Slow, stiff movements
- Clumsiness—loss of balance and coordination
Type MSA-C is associated with:
- Difficulty swallowing
- Problems speaking and hoarseness
- Difficulty coordinating muscle movement
As the disease progresses, symptoms will cross over types and become more severe. Many will develop muscle coordination problems and need walking aids. Other problems that may exist across type include:
- Problems with bladder control
- Erectile dysfunction
- Muscle tightening around a joint that prevents free movement
- Problems with posture, such as leaning to one side and forward head bend
- Inappropriate laughing or crying
- Excess yawning
- Vision problems
- Changes in writing
You will be asked about your symptoms and medical history. An exam of the nervous system will also be done. You will likely be referred to a specialist.
Your bodily fluids may be tested. This can be done with:
- Blood tests
- Lumbar puncture
Images may be taken of your bodily structures. This can be done with an MRI scan .
Tests will also be done on your heart rate and blood pressure. These tests will help determine what is causing problems with your autonomic nervous system. Nerve impulses to your muscles may also be tested.
There is no cure for MSA. Treatment will focus on managing the symptoms and supportive care. Talk with your doctor about the best plan for you. Options include the following:
Various medications may be used to manage the symptoms of MSA. Medication may be given to:
- Relieve muscle rigidity
- Stabilize mood
- Manage orthostatic hypotension
- Relieve other symptoms such as constipation, urinary control problems, or erectile dysfunction
- Physical therapy—to help keep muscles strong and maintain range of motion
- Occupational therapy—to improve ability to do daily tasks such as eating, grooming, and dressing
- Speech therapy—to help with speaking and swallowing
- Respiratory therapy— Continuous positive airway pressure (CPAP) for sleep apnea and other breathing problems during sleep
Dietary changes in salt and fluids may help manage orthostatic hypotension.
Soft or pureed foods may be helpful with swallowing problems.
A feeding tube may be needed in later stages of MSA. It will deliver nutrition directly to the stomach.
- Reviewer: Rimas Lukas, MD
- Review Date: 12/2014 -
- Update Date: 01/20/2015 -